Thursday, January 24, 2013

INX-189 clinical attrition - a call for re-look at single isomer strategy of Gilead?

October 2012
Discussion posted Pharmaceutical Discussion Group on LinkedIn


Is the purported toxicity of the non-active diastereoisomer in a P-chiral nucleotide prodrug (protide) a scientifically derived hypothesis OR is it merely a surmise from a coincidence that no active-isomer is found toxic till date? (considering very few 'single isomers' entered PI till date..)
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