Thursday, January 24, 2013

INX-189 clinical attrition - a call for re-look at single isomer strategy of Gilead?

October 2012
Discussion posted Pharmaceutical Discussion Group on LinkedIn


Is the purported toxicity of the non-active diastereoisomer in a P-chiral nucleotide prodrug (protide) a scientifically derived hypothesis OR is it merely a surmise from a coincidence that no active-isomer is found toxic till date? (considering very few 'single isomers' entered PI till date..)

The quintessential 'Indian vegetarian meal' prototype on Emirates

23 Nov 2012

On FB McKinsey article "the trouble with Travel distribution" 

http://www.facebook.com/mckinseyquarterly/posts/432757166778183




Yes indeed - the globe trotting traveler these days can negotiate and get deals on anything & everything, except if he/she's an Indian vegetarian, flying any global airlines and hoping for a gourmet food experience.... Get real chum, eat ur paneer, okhra, rice & all together :-l

Akbarnama

11th January on FB

Akbar bhai.... meraa bhi ek sawal hain aapko......jo baataan shadab cafe mein chai pe chotti samosa khatey waqat bolney hain, woh baataan camere ke samne kaiku karrain miyaan? panga kaiku lerain phursat mein khali-peeli sarkar sey? 

The mahaul at Nirmal is such that anyone can get into a rhetoric mode, get irrationally impassioned and indulge in senseless bravado....... while some of the allegations, sentiments voiced by Akbar bear a semblence to reality, truth, a lot of it was hyperbole & it would be foolhardy to say the listener would take it all as God's word...... Akbar is no polished politico, he comes across as immature, kiddish...... more than what he said about the infamous 'pandrah minute', more worrying is the way the crowd erupted in cheer & approval of that idiotic posturing........... dimaag khaan bhoolkey phirrain yaaron ye logaan?

Secular India would do good to focus on the funny side of all this & show it to the understanding Muslim population out there which also has a sense of humor... (believe me... there were a few concerned, confused and amused faces right behind the sher-e-deccan :-)...) to me this speech is nothing more than a excitable shahri showing off to the vulnerable dehathi....

(main section is between 48th & 60th minute)




Climb down from the towers BoDs..

We are all Board Members on LI by Lucy P Marcus

http://www.linkedin.com/today/post/article/20121120235138-60894986-we-are-all-board-members?trk=mp-reader-card

As an employee who always worked with a sense of ownership, accountability, I always felt its strange that the board's engagement with key employees (second line, executing level) within the organization is non-existent & more often than not, its strategic guidance is based on a colorful slide-deck or an birds-eye-view executive summary that rarely reflects the subtler aspects of business realities and it's short & long-term sustenance. While I see a common thread here that the board has a responsibility towards company's vision & and should represent the stakeholders interest rather than it’s own, I am wondering why so many critical decisions are still taken by boards without ever engaging directly with the stakeholders that actually go about translating the vision into action? & I’m presuming that employees at key positions too are considered a part of the stakeholder pool & not just the investing PE universe.

Provoke, par zara bachkey :-)


Want to Deepen Impact in 2013? Be a Provocateur on LI by Ben Mangan


Quite nicely provoked :-)... I though see most provocateurs use the 'why' primarily for disruptive purposes (unfortunately) than otherwise.... I guess these belong to the category of 'those who don't give a damn (like Veronika J wrote below...), but provoke nonetheless for the heck of it' (OR to topple some apple-carts...) Whichever type one is, my message to all prospective provocateurs is "Ask WHY?, but be well prepared when countered by 'WHY NOT'?" 

Wednesday, January 23, 2013

Your message bothers me Esther and how....

Should I Bother With Your Message? Persuade Me! on LI by Esther Dyson 

http://www.linkedin.com/today/post/article/20130116205459-28157-should-i-bother-to-read-your-message-persuade-me?goback=%2Eptf_*1_*1_*1_*1_recentPosts_*1&trk=who_to_follow-b


With all respect to the departed soul, I'm starting to get why Aaron Schwartz decided to end his life...... sender of a message pays on a social network? - Monetizing a few lines as though it were a validated piece of patented intellectual property? – bad enough reason for any cyber-socialist to give-up on hope and die! 

I remember & believe that cyber communities/ DBs started out in a spirit of sharing knowledge, thinking & perspective with whoever displays a similar trait to engage & evolve. If companies like LI & FB monetize this engagement for their own stock valuations, I still understand, particularly seeing how FB is struggling with its sub-par listing & trading post such a hyped-up public issue. What I don't understand is the increasing tribe of self-appointed thought-leaders & experts who believe a mere mail to them deserves a valuation!!!!! – Is it that I should’ve been a citizen of Pandora OR Is this really the most obscene manifestation of assumed self-importance? 


If I have a need that requires me to pay to someone just so that he/she receives my mail in a non-spam folder & for which he/she may not necessarily respond even, I’d think my need itself is ill-articulated &/or illegitimate and the person whom I’m trying to pay to get through to isn’t worth reaching out to after all 


Indeed, a good self-image is important in life..., but gents & ladies extreme self-importance is avoidable - never forget the “Rule Number 6” (http://dannyhageman.wordpress.com/2011/06/21/never-forget-rule-number-six/) 


Cheers


Saturday, November 24, 2012

Back with a BLOG!!

It has happened! - the progressive, unavoidable & of course overt monetization of the cyber social space has made me invisible to myself let alone others on my own home page! 

I’ve been noticing that my status updates aren't what they used to be....., LinkedIn hides them on the side-bar, FB sweeps them under the carpet of paid postings & decorates them with weird hyperlinks and Twitter turned into a whimper for all non-celebrities. The marginalization of my thinking on LI is so complete that my comments on the LI Today articles don't show-up on my activity nor I get any email alert for the same! & I'm a bit too old fashioned to spam my way to attention by liking, sharing every crap out there & post remarks against updates & articles on which I neither have an interest nor knowledge on.

Without sounding too narcissistic, I want to admit that I'm none too happy with many of my posts, comments, observations & tweets, thereby much of my perspective that I feel has some merit doesn't get enough eye balls to gather others perspective & thus validate my own.

Hence here I'm again, blogging after a mammoth sabbatical of 66 months! Without being repetitive in this era of information overkill, here I'll try and only recapture some of my social media updates, if not for anything else, as a way of chronicling my own honest thoughts in one place and thus escaping the drudgery of having to go through reams of digital pages before I can find out what I've said earlier in 2010 on LI/ FB/ Twitter.

If in the bargain I get some audience..., hey why not? bring 'em on :-)

Cheers!